The objective of the study was to evaluate the efficacy and safety of a Unani formulation Sharbat Zoofa Murakkab in the management of Sual Ratab (productive cough). ‘Sharbat Zoofa Murakkab’ in a dose of 10 ml, thrice daily was administered orally to the patients for 14 days. The Mean ± S.E.M. scores of signs and symptoms of Sual Ratab (productive cough) i.e. frequency, intensity, quantity, sore throat, hoarseness of voice and chest tightness were found decreased by 44.0% (p<0.001), 53.62% (p<0.001), 23.96% (p<0.001), 39.89% (p<0.001), 49.42% (p<0.001) and 58.09% (p<0.001) respectively as compared to in baseline findings. After treatment, the variation in biochemical parameters of Liver and Kidney Function Tests were found non-significant. No adverse effect was found in the patients. ‘Sharbat Zoofa Murakkab’ was found effective and safe in the treatment of Sual Ratab (productive cough).