Lymphatic filariasis is endemic in approximately 80 countries and has been targeted for global elimination as a public health problem. In this study, 154 patients suffering from lymphatic filariasis were enrolled at Regional Research Institute of Unani Medicine, Patna. This study was divided in two groups. In Group A, 84 patients were registered and only UNIM 268+UNIM 270+ UNIM 271+ UNIM 272 coded drugs were given. In group B, 70 patients were registered and MM Therapy was given followed by Unani coded drugs UNIM 268+ UNIM 270+ UNIM 271+ UNIM 272. The study reports the effect on biochemical and pathological profile of lymphatic filariasis patients treated with Unani coded drug UNIM 268 with UNIM-270+UNIM-271+UNIM-272 with and without MM therapy. In hepatic function tests, SGOT was significantly reduced (p<0.01) in group A and B (p<0.05), SGPT was significantly (p<0.05) reduced in group A, but in group B non-significant reduction SGPT was observed. There were no changes observed in renal function markers after the treatment of coded drugs. Absolute eosinophil count and eosinophil (%) were found increased at baseline which were significantly (P<0.001) reduced after the treatment of Unani drugs in both groups. ESR was also found increased at the baseline which was significantly reduced (P<0.01) after the treatment of coded Unani drugs in both groups when compared to the (before treatment). There were no changes observed in total bilirubin, alkaline phosphatase, urea, createnine, uric acid after the treatment of coded drugs in both groups. Total leukocyte count was significantly (p0<0.05) reduced in both groups and no changes were observed in differential count after the treatment of Unani coded drugs in both groups. The study advocates the safety and efficacy of Unani coded drugs and suggests these drugs beneficial for lymphatic filariasis patients