The purpose of the study was to evaluate the safety and efficacy of new Unani formulation in Iktisabi qillat-e-Ifraz-e-darqia (autoimmune hypothyroidism) on five patients. For this purpose, decoction of semi-crushed powder made of six Unani herbal drugs was given twice daily in the morning and in the evening to the patients as per the method described in this paper for a duration of 90 days. The study was conducted in the year 2010-2011.The study period was one year. The patients were advised to take sour foods and fruits. After completion of the study, the therapy showed a significant improvement in the patients (p=0.07). The formulation had no any side effects and the patients felt overall sense of wellbeing and lighter. Details have been presented in this paper.