Qurs-e-Zarishk Sagheer (QZS) is a pharmacopoeal compound preparation known to possess hepatoprotective effect. Present study was designed to evaluate its protective and curative potential on liver enzymes in CCl4 (2 ml/kg of body weight i.p.) induced hepatotoxicity in rats. Ingredients of QZS in powdered form and its hydro alcoholic extract were used in the doses of 700 mg/kg, and 230 mg/kg body weight /day, respectively. Silymarin was used as standard drug in the dose of 100 mg/kg orally/day. Biochemical parameters including Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase and TBARS were determined along with the histological studies of liver tissues of all the animals. The elevation of marker enzymes and structural changes in histological reports of liver sections were taken as the indicators of hepatic injury. The study showed gross elevation of liver enzymes and histological changes in CCl4 treated animals, while the test drug in both doses forms showed significant enzymes lowering activity, which was comparable with that of Silymarin. Biochemical parameters showed better results in respect of extract while hisptopathological observations were almost similar in both groups. The study demonstrated that QZS possesses significant liver enzyme lowering effect in CCl4 induced hepatic injury indicating hepatoprotective effect.