Osteoarthrosis is the commonest life style disorder encountered by the society. In the western countries radiographic evidences of this disease is present in majority of persons by 65 years of age and about 80% persons more than 75 years of age; despite exhaustive work, still no satisfactory answer has been placed forward by the modern medicine, conservative measures are ineffective and produce various Adverse drug reactions. Whereas, the Unani physicians e.g. Galen, Ibn Sina, Razi, Majoosi, Akbar Arzani, Azam Khan & Kabiruddin has suggested Fasd as an adjuvent regimenal therapy for various types of Arthritis. Though venesection is in vogue, but its scientific validation has not been carried out so far about its safety, efficacy and mechanism of action. Therefore, to explore new alternatives and for scientific validation of Fasd, this study has been designed and carried out to evaluate the safety and efficacy; and to explore the mechanism of action of Fasd in the cases of Osteoarthrosis.