Plants secondary metabolites are a potential renewable source for use in human therapy. Secondary metabolites are widely extracted from the whole plant. Production and extraction of secondary metabolites for therapeutic use from whole plant posses certain problems. These problems include: environmental factors (drought, floods, etc.), disease, political and labour instabilities in the producing countries (often Third World countries), uncontrollable variations in the crop quality, losses in storage and handling. Plant Tissue culture is an attractive and beneficial alternative approach for the production of therapeutically important secondary metabolites in an efficient and time bound manner. Plant cell and tissue cultures hold great promise for controlled production of myriad of useful secondary metabolites on demand. The current review highlights a brief role of plant secondary metabolites in therapy and the history of their production through various techniques involved in plant tissue culture and the best suited media used for the production.