The concept of protection and tonicity of an organ as described in Unani medicine has a specific notation that can be understood through the theories philosophies that govern the system. This will help understand the significance of the theory and its practical application and also the nature and mechanism of drugs action and thereby their actual therapeutic

value. Evidences are accumulating to demonstrate that the drugs described to be useful in various renal disorders because of their nephroprotective and nephrotonic effect as described in Unani or other traditional medicines, have even more wide and diverse therapeutic uses than that depicted by the modern medicine practitioners. Many scientific studies have demonstrated that Unani medicine have ample potential to become an important source of managing many renal diseases and their complications. This paper gives a brief account of the concept of nephroprotection and explores the potentiality of Unani drugs that can be used to treat the renal diseases or at least arrest their progression to chronic or end stage renal disease.