The mucosal inflammation of the Paranasal sinuses may be acute or chronic process. The acute inflammation of the sinus mucosa commonly follows an attack of acute rhinitis as in common cold or influenza when the bacteria invade as secondary organisms (Dhingra, 2008). The effective treatment to manage this clinical entity is available in modern

medicine but there is a need of the time to develop a safe and curative treatment in the Indian system of medicine.

Hence the objective of the present study is to evaluate the efficacy of Unani formulation ‘Sinugard Granules’. The study was open single group uncontrolled clinical trial. In the present study forty cases of 13 to 57 years of age who were clinically diagnosed were enrolled in the study for 10 days from Moalejat and Otorhinolaryngology OPD, Ajmal Khan Tibbiya College, Aligarh Muslim University, Aligarh. The patients were treated with half sachet of ‘Sinugard Granules’ twice a day with lukewarm water. All the patients were assessed for subjective parameters. The study revealed that the Unani formulation has given good response on nasal congestion, tenderness and nasal discharge. Therefore, it can be concluded that the compound Unani Formulation ‘Sinugard Granules’ can be used for the treatment of Warm-e-Tajaweef-e-Anf (Sinusitis).