An ethnobotanical survey was undertaken to collect information on the use of ethnomedicinal plants in Boudh district of Odisha state in March, 2017. The exploration revealed folk use of 65 species of plants distributed in 64 genera belonging to 35 families to treat various ailments. The indigenous knowledge of local traditional healers and the native plants used for medicinal purposes were collected through questionnaire and personal interviews during the field trip. In this study the most dominant family was Euphorbiaceae and leaves were most frequently used for the treatment of diseases. Maximum species were used to cure dermatological conditions. The study enriches our existing knowledge on ethnopharmacopoea of this region of Odisha state which likely will contribute significantly to develop and discover new drugs of natural

origin.