Ethnobotanical field investigations of medicinal plants was carried out in Dhenkanal forest division, Odisha in March, 2014. During survey, 148 medicinal species were collected and identified from the study area. Of these, 21 species belonging to 20 genera and 14 families have been found to be used by local inhabitants for treating their common diseases and conditions.The information on folk medicinal uses of plants viz. botanical name, family, Unani name (if any), mode of application etc. have been presented in this paper.