Usre tams Ibtidayee (primary dysmenorrhea) is painful menses in women with normal pelvic anatomy, usually beginning during adolescence and appearing within 6–12 months after the menarche. Objective of the present study was to evaluate the efficacy of ‘Sharbat Bazoori Motadil’ on the intensity of pain and others associated symptoms of Usre tams Ibtidayee. Patients suffering with regular and painful menstruation cycles were administered orally 20 ml of ‘Sharbat Bazoori Motadil’ with water, twice daily from 7th day before to the expected date of menstrual cycle for two consecutive cycles. It was found that after treatment the intensity of pain and associated symptoms; lumbago, lower abdomen pain, leg cramps and nausea were significantly (p<0.05) reduced by 50.7%, 88.4%, 66.2% and 73% respectively as compared to baseline. After treatment, reduction in the pain and others associated symptoms of Usre tams Ibtidayee was the main outcome measure. Highly significant improvements (p< 0.001, paired ‘t’ test) in lower abdomen pain and nausea suggest that the results are really due to the therapy. In conclusion, Unani Paharmacopoeial formulation ‘Sharbat Bazoori Motadil’ was found effective in treatment of Usre tams Ibtidayee (Primary Dysmenorrhea) without any adverse effect on the human body.