A clinical trial was conducted on 50 patients of Grade I, II and III Acne Vulgaris with their age range from 10-40 years. The grade IV of the disease was excluded from the study. The already diagnosed patients were given Tab Musaffi in the dose of 2 tablets after meals along withfish bone)+badam-e-talkh(bitter almond)+arq gulab (rose water) twice daily for 28 days. After completion of therapy, there was a significant recovery in the symptoms of acne vulgaris in grade I and II and little in grade III. The results show that this formulation can be tried in such patients as an alternate. The details have been discussed in the paper.