Arctostaphylos uva-ursi (L.) Spreng. is well known medicinal plant for the treatment of cystitis (bladder inflammation) and kidney catarrh (mucous) and the official drug of Homoeopathic System of Medicine. The leaves of Uva-ursi have high trade value in the national and international markets in the herbal drug industry. The leaves of Cowberry (Vaccinium vitisidaea L.) and the Box (Buxus sempervirens L.) are commonly adulterated with the leaves of Arctostaphylos uva-ursi (L.) Spreng. Present communication deals with the morphological and anatomical characteristic features of the leaf of Arctostaphylos uva-ursi (L.) Spreng. and also the comparative characters of its possible adulterants Vaccinium vitis-idaea L. and Buxus sempervirens L. with a view to check adulteration in the genuine drug to ensure manufacture of quality medicines.