Zaght-ud-dam qawi ibtidai (Primary hypertension) is a disorder affecting the population at large. According to British Hypertension Society, hypertension is the level that exceeds the high normal level of 140/90 mmHg. Six Studies from different institutions were taken to compare their efficacy in the management of this disorder with Unani Drug combinations. Though all the drug combinations i.e. (i) Itrifal Kishneezi; (ii) Khameera Sandal Sada; (iii) Qurs Dawaus Shifa; (iv) Safoof-e-Kahu-Khar Khasak; (v) Safoof-e- Khashkhash & Sharbat-e-bazoori motadil and (vi) Safoof-e-Musakkin were proven to be effective but the most effective combination to normalise systolic blood pressure was found to be Safoof-e-Kahu-Khar Khasak while the most effective combination to normalise diastolic blood pressure as well as the symptomatology was found to be Safoof-e-Musakkin. Thus, after comparing the efficacy of all the Unani drugs combinations, ‘Safoof-e-musakkin’ can be proposed to be the most effective Unani drug combination to be used for the management of zight-ud-dam qawi ibtidai, with best results.