Trichomoniasis is a common infection worldwide. It is found in approximately 50% of the patients who complain of vaginal discharge and over 200 million people worldwide become infected every year with it. Unani Drug reports show highly divergent prevalence rate of trichomoniasis in different countries and even in different geographical regions. The World Health Organization has estimated that this infection accounts for almost half of all curable infections worldwide. In spite of the wide prevalence of this disease, the choice of treatment available in western is limited and the recurrence rate is very high after the treatment and symptomatic relief. Tibb-e-Unani claims to possess a number of effective and safe therapeutic agents which are used commonly in the treatment of trichomoniasis however the scientific data validating their efficacy are very few. Therefore, in the present study an attempt has been made to evaluate a pharmacopoeial Unani preparation viz. Marham Dakhliyun on 60 patients for its efficacy in the management of trichomoniasis. The ointment was locally applied over vaginal mucosa and fornices in a dose of 5 gm, at bed time, for 14 days. Patients treated with test drug showed 86.6% reduction in important clinical features such as abnormal vaginal discharge, pruritus vulva and trichomonas in wet mount examination. The findings suggested that Unani drug Marham Dakhliyun is effective in the treatment of trichomoniasis.