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Clinical Evaluation of Efficacy of a Unani Formulation in Waja-ul-Mafasil “Rheumatoid Arthritis"

Qamar Uddin, L. Samiulla and Fasihuzzama

Hippocratic Journal of Unani Medicine
Hippocratic Journal of Unani Medicine January - March 2012, Vol. 7 No. 1, Pages 1-11


In the classical Unani texts, Waja-ul-Mafasil is broadly explained and well correlated with a chronic inflammatory joint disease, rheumatoid arthritis (RA). The exact aetiology of rheumatoid arthritis is still unknown and there is no curative treatment for this chronic, painful, disabling disorder. In Unani system of medicine, many single drugs (Mufrad Adviyah) as well as compound formulations (Murakkab Adviyah) are being prescribed since ages for the treatment of Waja-ul-Mafasil. Therefore, a randomized, controlled, single-blind clinical trial was conducted to evaluate the therapeutic efficacy of three Unani herbal drugs (Withania somnifera, Piper nigrum, and Datura fastuosa) in comparison to a control drug (Aspirin) in patients of Waja-ul-Mafasil. The study was carried out on 40 patients of Waja-ul-Mafasil. The symptoms and signs of the disease after 21 days of treatment showed significant improvement with no adverse effects of test drugs in comparison to control drug. The study is affirmative of the therapeutic efficacy and safety of the Unani test drugs combination in patients of Waja-ul-Mafasil. However, there is a need to carry out further study with a large sample size and with assessment of effect on specific anti-TNF antibodies to establish the possible curative treatment to tackle this global problem.

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