A Randomized single blind standard controlled clinical trial was designed to evaluate the effi cacy of decoction of a non pharmacopoeial Unani formulation in the patients of Zeequn Nafas Shoabi (Bronchial Asthma) during 2009-2010. Forty patients of Bronchial Asthma, were randomly allocated to Group A (Test) and Group B (Control), comprising of 20 patients each by lottery method. Patients in Group A were treated with the test drug Aslussus (Glycyrrhiza glabra), 4 g; Abresham (Bombax mori), 3g; Gauzaban (Borago offi cinalis), 4 g; Zoofa Yabis (Hyssopus offi cinalis), 3g; and Saboose Gandum (Triticum aestivum), 6 g) in the form of Joshanda (Decoction) whereas Salbutamol (Asthalin) inhaler was used as a control drug in Group B. The treatment was given twice a day for a period of 45 days. All the patients were assessed for subjective (Cough, paroxysmal dyspnoea and wheeze etc.) and objective (FEV1, FEV1/FVC and PEF) parameters on 0, 15th, 30th and 45th day. The fi ndings were analyzed by appropriate statistical tests. A signifi cant improvement was noted in subjective and objective parameters in both groups (p<0.05). The study revealed that the test drug is effective in the treatment of Bronchial Asthma