In the present study the combined effect of two well documented and well known herbal drugs Azadirachta indica Juss. & Trigonella foenum-graecum Linn. have been studied in Type 2 Diabetes mellitus patients. Medicinal plants have been mentioned by various authors for their hypoglycaemic activity. Therefore, we choose two medicinal plants to check the effi cacy of these drugs in diabetes mellitus. The drug was given in powder form in the dose of 6gm twice a day for 3months. The results were analysed statistically. There was statistically signifi cant reduction in the fasting and post prandial blood glucose (t=8.3, p < 0.001) (t=8.6, p<0.001) respectively. The signifi cance on glycated haemoglobin was (t=4.4, P<0.001). The signifi cance on total cholesterol was (t= 5.1, p< 0.001). The signifi cance on effect of drug on glycosuria was (t=6.1, p<0.001).