Unani drug Anisoon, the seeds of a plant Pimpinella anisum Linn, is one of the oldest spices and important medicinal herb mentioned by Greek and Roman Unani physicians in their treatises for its diverse therapeutic properties centuries ago. It is one of the most ancient crops cultivated in the eastern Mediterranean Region, Western Asia, the Middle East, Mexico, Egypt, and Spain. In Unani system of medicine, it is used as Kasir-e-riyah, Mohallil- e-Riyah, Muqawwi-e-Meda, Mushtahi, Mufatteh, Mufatteh Sudad, Munaffis-e- Balgham, Mukhrij-e-Balgham, Muddir-e-Bol, while in ethno-medical literature it has been described to be mild expectorant, stimulant, carminative, diuretic, and diaphoretic showing that the plant has diverse biological and pharmacological activities. Keeping in view its high medicinal importance in Unani medicine, a comprehensive review based on Unani, ethnobotanical, phytochemical and pharmacological literature has been presented with an aim to expose new frontiers

for research and therapeutic application of anisoon.