A series of medicinal plants collection trips to various forest regions of South Western Ghats of Tamil Nadu, have brought to light 53 plants species widely used in the study area to treat certain non-communicable diseases as per Unani text. All species collected have been analyzed in respect of their diversity, life form and taxonomic category. The study reveals that many such species are either rare or endangered and needs immediate attention for their conservation and protection, through germiplasm collection initiatives before these are lost for ever. All species have been listed providing information on their botanical name, family, Unani name, therapeutic uses as per Unani text. Further scientific studies are suggested with a view to discover new drugs of plant origin to combat many such non-communicable diseases, hitherto incurable, in modern medicine.