Hypertension the “silent Killer” is considered to be  a major health problem throughout the globe. This is due to high prevalence  and its association with increased risk of cardiovascular complications. In spite of increasing public awareness and a rapid advancement of anti- hypertensive medications hypertension still remains one of the leading cause of cardiovascular morbidity and mortality. The term hypertension or Zaght al-Dam-Qawi has not been mentioned in any of the classical unani literature. The term hypertension was first used by Harry Gold Ballet in 1934 and the term Zaght al-Dam-Qawi was used by Unani scholars contemporary to Indian period. But most of the Unani scholars were familiar to manifestation of hypertension, as they have described most of its symptoms such as headache, palpitation, vertigo and epistaxis, due to imtala (repletion). Some of them even described vascular pressure by increased blood volume in lumen of blood vessels.

To evaluate clinical efficacy of drugs in hypertension, Qurs-e- Dawaushifa was chosen which contains Asrol (Rauwolfia serpentina Linn) and Filfil siyah (Piper nigrum Linn.). This drug for hypertension is proposed keeping in mind the side effects that directly arise after the administration of the drug for relatively longer period. Hence, an attempt has been made to evaluate the efficacy of these drugs on modern parameters in patients with essential hypertension.

The study was concerned with comparison between Qurs-e-Dawaushifa and Amlodipine in the treatment of primary hypertension. Hence all the 50 patients were divided into two groups, control and test group. Each group consists of 25 patients. Control group was treated with amlodipine and test group was treated with Qurs-e-Dawaushifa. All the results were analysed statistically.