The therapeutic efficacy of Unani coded drug UNIM- 855 was evaluated in 30 patients of tooth hypersensitivity of either sex ranging in age from 20 to 60 years. 2 gm of the test drug as fine powder was advised to be rubbed over the surface of the gums and teeth by the index finger and left for five minutes then rinse with fresh water. Scoring for tooth hypersensitivity was done before treatment and at weekly intervals after initiating the treatment. Treatment was given initially for 15 days and extended up to 60 days if required. Out of 30 cases, 12 got 100% response, 10 got 71-99% response, 2 got 51- 70% response, 4 got 31-50% response and 2 got no response. Thus the Unani coded drug UNIM- 855 is shown to be quite effective in reducing the tooth hypersensitivity.