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Hepatoprotective Activity of Extracts and Chemically Defined Molecules from Herbal Drugs - Review

Manoj Kumar Pandey, Nitin Rai and Rajeev Kr. Sharma

Hippocratic Journal of Unani Medicine
Hippocratic Journal of Unani Medicine July - September 2014, Vol. 9 No. 3, Pages 67-90


Liver diseases have become one of the major causes of morbidity and mortality in man and animals all over the globe and hepatotoxicity due to drugs appears to be the most common contributing factor. About 20,000 deaths occur every year due to liver disorders. Hepatocellular carcinoma is one of the ten most common tumors in the world with over 2, 50,000 new cases each year. Plants have potent biochemical components of phytomedicine. Plant based natural phyto-constituents can be derived from any morphological part of the plant and may contain active components. The beneficial medicinal effects of plant materials typically result from the combinations of secondary products present in the plant. The medicinal actions of plants are unique to a particular plant species or groups and are consistent with this concept as the combination of secondary products in a particular plant is taxonomically distinct as such different types of drugs such as acetaminophen; chloroquinine and isoniazid are inducing hepatoxicity in the world. Herbal plants have been used traditionally by herbalists worldwide for the prevention and treatment of liver disease so. Herbal drugs were prescribed even when their biologically active compounds were unknown because of their effectiveness, few side effects and relatively low cost.

In this review, an attempt has been made to compile the reported hepatoprotective activity of plants from India and abroad and may be useful to develop evidence based medicine to cure different kind of liver diseases in man and animal.

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