Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine January - March 2015, Vol. 10 No. 1, Pages 15-22

Toxicity Study of Qurs-e-Hudar in Experimental Animals

Mohd Nadeem, Mohd Urooj, Habibur Rahman and Shariq Ali Khan

Abstract

The present study was carried out to investigate the safety of Qurs- e-Hudar by conducting acute and sub-acute toxicity in Swiss albino mice & rats respectively. Acute toxicity was determined by administering aqueous extract of Qurs-e-Hudar orally to two groups of mice of six each at a dose 1gm/kg and 2gm/ kg body weight. The animals were observed for gross behaviour and mortality for 24 hours after drug administration. The formulation was well tolerated by the animals and no abnormality was observed in the general behaviour of the animals and no overnight mortality was recorded. Similarly, Sub-acute toxicity was determined in albino rats by orally administration of aqueous extract to three groups of seven animals each at a dose ranges from 1 gm/kg and 3 gm/kg body weight for 28 days. The results of haematology and biochemistry profile done on 29th day were found to be normal and no changes were observed in organ to body wt ratio of liver, heart, kidney and spleen.

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