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Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine July - September 2013, Vol. 8 No. 3, Pages 43-68

The Study of Viral Hepatitis and Comparative Evaluation of Kabdeen, Liv-52 and Lamivudine in its Management

Rafiullah, M.M.H Siddiqui and M.H Hakim

Abstract

Acute Viral Hepatitis (Warm-e- KabidHaadVairoosis) is one of the commonest liver diseases caused by one or more of the five viral agents. Among them, Hepatitis-B virus is a leading cause of mortality and morbidity owing to its dreadful complication such as Cirrhosis,

Carcinoma of the liver and Hepatic Encephalopathy. Despite a remarkable development in the field of medical science, no convincing treatment is available in any system of medicine. Hence, researcher of every medical field is trying to develop safe and efficacious drugs for its management. In Unani system of Medicine, phyto-medicines as a whole or their formulations are widely used for the cure of liver derangements but the efficacy of these drugs have not been scientifically evaluated so for. Therefore, a comparative study has been designed to evaluate the efficacy of Kabdeen (a non Pharmacopial Unani formulation) and to compare its efficacy with Liv-52 and the standard drug Lamivudine for the management of Hepatitis B.

For this purpose thirty diagnosed patient of Hepatitis B have been selected from A. K. Tibbiya College Hospital, AMU Aligarh. The patients were divided into three groups; Group A Group, B and Group C (Comprising ten patients in each group). Group A was treated with Kabdeen 10 ml three times a day, Group B was treated with Liv-52 two Tablets twice a day while Group C was treated with standard drug Lamivudine100 mg one Tab once a day for the period of 60 days. All the patients were assessed for subjective and objective parameters every fortnightly. At the end of the study data was statistically analyzed.

The study revealed that all three groups were effective in alleviating the subjective symptoms and normalizing the biochemical markers of LFT in the patients of Hepatitis B. It was also observed that HbsAg had become negative in four patients of group A, three patients in Group B and six patients in Group C. Therefore, it can be concluded that the test drug Kabdeen can be safely used for the management of Hepatitis B.

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