Preparation and Physicochemical Evaluation of an Antidiarrhoeal Safoof

Ubaidul Hai, *Shariq Shamsi, Roohi Zaman and Peerzada Mohd Younis

Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine January - March 2016, Vol. 11 No. 1, Pages 121-136

Abstract

Diarrhoea is one of the global public health concerns now a days. In Unani System of Medicine (USM) various anti-diarrhoeal formulations are used for the treatment of diarrhoeal diseases. For the assurance of safety, efficacy and reproducibility, it is mandatory that every herbal product should pass the tests of identification, authentication and physico-chemical stanardization. In the present study, a Unani anti-diarrhoeal Safoof (ADS) was prepared and its quality standards were established. After preparation of powder dosage form (ADS), it was evaluated on pysico-chemical parameters which included organoleptic properties; alcohol soluble matter; water soluble matter; successive extractives; ash values; moisture content; loss of weight on drying; pH in 1% solution and 10% solution; angle of repose; bulk density; tapped density; carr’s index; hausner’s ratio; volatile oils; qualitative estimation; quantitative estimation and TLC finger printing. The results of standard parameters of ADS have shown alcohol soluble matter (23.964 ± 0.03%), water soluble matter (17.381 ± 0.06%), moisture content (3.661 ± 0.33%), loss of weight on drying (7.156 ± 0.04%), pH in 1% solution and 10% solution (6.83 ± 0.04 and 5.67 ± 0.03 respectively), angle of repose (51.3469 ± 0.50), bulk density (0.3216 ± 0.00 gm/ml), tapped density (0.4245 ± 0.00 gm/ml), carr’s index (24.2452 ± 1.02), hausner’s ratio (1.3205 ± 0.01), volatile oils (3.066 ± 0.13%) and tannins (2.54 ± 0.04%). Various chemical constituents were also found positive. The TLC finger printing showed five spots on silica gel plate. These developed physicochemical standards of ADS may be used for future reference.

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