Evaluation of antiinflammatory activity of Habbe-Gule Aakh in albino rat

M. Nafees, N. A. Khan, K. M.Y. Amin and Ghufran Ahmad

Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine October - December 2012, Vol. 7 No. 4, Pages 1-9

Abstract

In the present study, Habbe-Gule-Aakh (HGA)-a Unani pharmacopoeial preparation, was studied for anti-inflammatory effect. Carrageenan-induced rat paw edema test and Cotton pellet implant test were used to determine the effect against acute and sub-acute inflammation, respectively in different groups of albino rats treated with HGA in the dose of 400, 750 and 1000 mg/kg. Diclofenac sodium was used as standard drug. In Carrageenin-induced rat paw edema, the maximum effect was observed at three hours when HGA produced 26.32%, 47.3% and 50% inhibition of inflammation, respectively. In Cotton pellet implant test, it was found to induce inhibition of 30.94%, 47.78% and 49.80% of granuloma formation. HGA demonstrated significant anti-inflammatory activity in both acute and sub-acute inflammatory condition. The effect in sub-acute inflammation was found more pronounced

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