Evaluation of Hypoglycemic Effect of Qurse-Ziabetus Khas in Alloxan Monohydrate Induced Diabetic Albino Rabbits

Azhar Javed, Aziz ur Rahman and Tajuddin

Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine January – March 2017, Vol. 12 No. 1, Pages 1-10

Abstract

This study was carried out to evaluate the use of Qurs- e-Ziabetus Khas in hyper-glycaemia clinically. The anti-diabetic effect of Qurs-e-Ziabetus Khas was studied in adult healthy albino rabbits of either sex weighing 1.5-2 Kg at the doses of 400, 800 and 1200 mg/kg orally in the form of suspension. The animals were randomly divided into diabetic control, diabetic treated and standard groups, and each group consisting of 6 rabbits. Initially animals were made diabetic by injecting alloxan monohydrate at the dose of 150mg/Kg intravenously. The blood samples were obtained from the marginal ear veins at 0 h (initial), and after the test drug administration at 2, 3 and 6th hour. Blood glucose was estimated by the End Point O-Toluidine method. The maximum reduction of blood glucose occurred after 3rd hour of test drug administration at the dose of 1200 mg/kg orally as compared to animals of control group. The test drug was also compared with a standard drug glibenclamide in a dose of 1.5 mg/kg. The obtained data were analyzed by one way ANOVA with post hoc‘t’ test. The findings indicate that the Qurs-e-Ziabetus Khas has significant effect in non insulin dependent diabetes mellitus and scientifically validated the claims of

Unani physicians that this drug possesses antidiabetic effect.

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