Clinical Evaluation of Anti–Hyperlipidaemic activity of a Unani formulation containing Ritha (Sapindus trifoliatus Linn), Methi (Trigonella foenumgraecum Linn) and Bartang (Plantago major Linn)

Z.Sharique, Hamiduddin, A.H. Malik, Amanullah and A. Hasan

Hippocratic Journal of Unani Medicine

Hippocratic Journal of Unani Medicine April - June 2013, Vol. 8 No. 2, Pages 9-21

Abstract

Hyperlipidaemia is a metabolic disorder. It produces diseases like atherosclerosis, coronary heart disease (C.H.D) etc, which has an irreversible & fatal systemic effect. Majority of conventional allopathic drugs such as Statins and Fibrates etc have various adverse effects.

An effective, safer, cheaper and readily available solution is needed to deal with Hyperlipidaemia. A compound formulation was prepared for this clinical study containing Methi (Trigonella foenum–graecum Linn) seeds, Tukhme Bartang (Plantago major Linn) seeds and rind of Ritha (Sapindus trifoliatus Linn) fruit. Muqil (Commiphora mukul Hook ex Stocks) a gum resin was taken as standard drug. Patients were selected from OPD of Mohammadia Tibbia College and Assayer hospital, Malegaon (MS) and randomly divided into two groups ‘A’and ’B’of 30 patients in each of either sex. In group ‘A’ test drug was given in a dose of 6.1 g. and in group ‘B’ standard drug Muqil (Commiphora mukul Hook ex Stocks) in the dose of 1 gm was given before meals, three times a day for the period of 60 days. Assessment of efficacy was done on the basis of lipid profile. Both the groups exhibited highly significant anti hyperlipidaemic activity (p<0.001) except HDL (High density lipoproteins) level in standard control group. Test drug reduced the total Cholesterol (14.69%), TG (Triglyceride) (26.81%), and LDL (Low density lipoproteins) level (18.98%) and increased the HDL level (10.05%). Possible lipid lowering action of the test drug may be attributed to different constituents, such as saponin, mucilage, fiber, etc. Test drug exhibited highly significant antihyperlipidaemic activity and is as effective as standard drug.

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References